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37 year old mant who had an incidental mass seen in the liver on MRI. He is asymptomatic.
Early flow and blood pool images show focal area of decrease radiotracer activity in the right lobe of the liver. Delayed images show a large round focal area of intense increase in radiotracer uptake. This corresponds to the previously seen area of photopenia.
MRI images on T1 shows a large mass with heterogeneous signal intensity and T2 shows the mass to have high signal intensity.
Differential includes hemangioma, hepatoma, and angiosarcomas. Findings are consistent with Hemangioma of the liver. Criteria for diagnosis of a hemiangioma on Technetium-99m labeled red blood cell (Tc99m-RBC) scan require the liver mass to have increase activity on 1 or 2 hour delayed imaging. Blood flow images usually show decrease uptake but can show early uptake. Large hemangiomas can show heterogeneous uptake.
Diagnosis of a hemiangioma on Tc-99m RBC scan has a very high positive predictive value (approaching 100%). Rare false positives have been reported for hepatomas and angiosarcomas. False negative studies are also rare and may be a result of fibrosis or thrombosis. Planar imaging can demonstrate hemangiomas from 3 cm and greater. Multiple headed SPECT can detect hemangiomas from 1.5 cm and greater.
Ref: Thrall, James, Nuclear Medicine: The Requisites, 1995, pp 204-210
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