| Print Date: | May 23, 2013, 8:42 am |
| Title | Autosomal Dominant Polycystic Kidney Disease |
| Text | Autosomal Dominant Polycystic Kidney Disease is the most prevalent genetic disorder in the United States that causes renal failure. ADPKD is localized to a gene on short arm of chromosome 6. This condition usually presents in the 4th decade with equal male:female prevalence. Most common presenting symptoms include hypertension, palpable mass, abdominal pain, hematuria and urinary tract infection. Complications associated with these cysts include renal failure, bleeding, obstruction and infection. Radiographic findings include total replacement of renal parenchyma by simple and complex cysts (commonly hemorrhage) in end-stage disease. In early disease unilateral enlargement without identifiable cysts may be the first stage of the disease. ADPKD is associated with hepatic (30-60%), pancreatic (10%) and rarely other organs. The most important association is with cerebral “berry” aneurysms (approx 10%) that can be fatal and therefore patients should be sceened with MRA once they have been diagnosed with ADPKD. |
| References: | Pollack, H. Clinical Urography. W.B. Saunders. 1990. Vol 2. pp1091-1010. |
| Contributor | Seth D. O'Brien (National Capital Consortium) |
| Peer Reviewer | Richard J. Choi (Walter Reed Army Medical Center) |
| Record Number | : 3776 |
| Created | 2002-05-02 22:33:29-04 |
| Modified | 2004-06-09 16:16:34-04 |
| Category: | Congenital, genetic |
| Location: | Genitourinary |
| Sublocation: | Kidney |
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