|Print Date:||May 25, 2013, 9:20 am|
|Title||Anaplastic Astrocytoma, WHO Grade 3|
|Text||Astrocytic tumors are the most common primary intracranial neoplasms. The WHO has devised a four-tiered grading system. Grade I and II are considered low-grade astrocytomas and are more common in children. The majority of astrocytomas occurring in adults are high-grade, grade III and IV. They are usually supratentorial and have poorly defined margins. Tumor cells migrate away from the main tumor mass and invade adjacent tissue, often traveling along white matter pathways. Therefore, imaging studies do not usually reveal the full extent of the tumor.
Although all of these tumors are eventually fatal, longer survival has been associated with younger age, better clinical performance status, and greater extent of surgical resection. Mean survival for high grade glioma patients younger than 65, treated aggressively, is 11 to 13 months.
|References:||Braunwald, et al., Harrisonâ€™s Principles of Internal Medicine, pp 2444-2445, McGraw-Hill, (Philadelphia, 1997).|
|Contributor||MS-4 USU Teaching File (Uniformed Services University)|
|Author||ENS Tom Landers|
|Peer Reviewer||James G. Smirniotopoulos, M.D. (Uniformed Services University)|
|Record Number||: 5009|
|Location:||Brain and Neuro|
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