|Print Date:||May 24, 2013, 7:13 am|
|Title||Brain tumors, Incidence|
|Text||J Trop Pediatr 1991 Mar;37(2):64-6
Primary pediatric brain tumours in Barbados: 10-year analysis (1978-1988).
Lashley PM, Clarke H, Archer EY
The case notes of 29 children ranging in age between 6 months and 17 years were reviewed for the period 1978-88. This study was done to determine if there were any differences when compared with other series in the developed countries. In addition, the distribution, tumour type, clinical presentations, and outcome were reviewed. Of the 29 tumours, 15 tumours were confined to the posterior fossa (52 per cent), and tumours were located supratentorially (48 per cent). Of the 15 tumours in the posterior fossa, five were medulloblastomas, four brain stem astrocytomas, and six cerebellar astrocytomas. The supra-tentorial tumours included, five astrocytomas, two pituitary tumours, two cranio-pharyngiomas, one hypothalamic glioma, and four intraventricular tumours. Clinical presentation was confined to symptoms and signs related to raised intracranial pressure, ataxia, seizures, and cranial nerve involvement. All the tumours were resected surgically except for the brain stem tumours, which were treated in most cases with radiation therapy. The overall mortality was 48 percent (14 patients died). We were unable to comment on long-term survival except for a 100 per cent survival in patients with pituitary and cerebral tumours, and 67 per cent in patients with cerebellar astrocytomas.
PMID: 2027166, UI: 91226006
Rev Neurol 1999 Jun 16-30;28(12):1153-8
[Tumors of the posterior fossa in children].
Sardinas N, Marcos R, Pestana EM, Vargas J, Chi-Ramirez D, Rojas E, Esteban EM, Zarrabeitia L
INTRODUCTION: Primary tumours of the CNS form 20% of the neoplasias seen in children. They are the second commonest type of cancer seen in childhood, after leukemia. A significant proportion of paediatric cerebral tumours (> 50%) are intratentorial.
OBJECTIVE: To find the frequency and clinicopathological behavior of posterior fossa tumours in children seen at our hospital.
PATIENTS AND METHODS: From the hospital records, a descriptive, retrospective study was made of 112 children with tumours of the posterior fossa who were attended at the Institute of Neurology and Neurosurgery between January 1980 and December 1997. The variables: age, sex, clinical findings, site and extent of the tumour and its histological description were recorded. The mean, standard deviation, frequency distribution and chi-squared test were used, depending on the type of variable to be analyzed.
RESULTS: The age of the patients when the diagnosis was made was between 8 months and 15 years (mean = 8.32 years). The male/female ratio was 59/53 (1.1/1). The commonest site of the tumours was the cerebellum (58.9%). The predominant histological types were medulloblastoma (33.92%) and astrocytoma (19.64%) in the cerebellum, glioma in the brain stem (10.71%) and ependymoma in the i.v. ventricle (8.09%).
CONCLUSIONS: Endocranial hypertension and the cerebellar syndrome were the predominant clinical findings in medulloblastoma, cerebellar astrocytoma and ependymoma. In brainstem gliomas there was often involvement of several cranial nerves and long tracts.
PMID: 10478374, UI: 99407812
Arq Neuropsiquiatr 1997 Dec;55(4):795-800
[Primary pediatric tumours of the central nervous system. Anatomopathological study of 623 cases].
[Article in Portugese]
Torres LF, Jacob GV, Reis-Filho JS, de Noronha L
Tumours of central nervous system (CNS) represent the second most frequent malignancy in children under 15 years of age but are the commonest cause of death. The authors present the epidemiologic and histopathologic analysis of 623 primary tumours of CNS occurring during the period 1990 to 1996 in paediatric patients. In this period 3318 biopsies of CNS were analyzed. In this total were included 623 paediatric tumours (18 7%). The age of patients ranged from 5 months to 15 years, 325 tumours occurred in males and 298 in females. The majority affected the posterior fossa. The majority of paediatric neoplasias were of glial origin (n = 277). The most frequent tumours were: astrocytoma (27.9%), medulloblastoma 9.95%), craniopharyngioma (5.93%), ependymoma (4.97%) and glioblastoma (3.37%).
PMID: 9629340, UI: 98292985
|References:||; Accepted by jsmirnio; Accepted by jsmirnio|
|Contributor||James G. Smirniotopoulos, M.D. (Uniformed Services University)|
|Peer Reviewer||Approval is Pending|
|Record Number||: 642|
|Location:||Brain and Neuro|
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