| Print Date: | June 19, 2013, 4:38 pm |
| Title | Bilateral Optic Gliomas |
| Text | Lesions/Condition: Optic Glioma Cell of Origin: Glial cells of varying differentiation Associations/Predisposing Factors: Neurofibromatosis I in children. The adult form has no association with neurofibromatosis. Common Locations: Anterior – orbital, infracannalicular, intracranial Posterior – chiasmal, hypothalamic, anterior third ventricle Demographics: most commonly in children (90% before 20, 75% before 10) Radiology: MRI - A tubular thickening of the optic nerve and chiasm A suprasellar tumor with contiguous optic nerve expansion A suprasellar tumor with optic tract involvement Prognosis and Treatment: Children have a good prognosis, worse in patients with chiasmal lesions. Spontaneous regression reported in some children with NF1. Adults have poorer prognosis, these lesions are either anaplastic astrocytoma or glioblastoma multiforme and are locally aggressive. Treatment is often chemotherapy initially with subsequent surgical resection. Radiation is effective, but neurologic sequelae prevents widespread use. |
| References: | Alvord, EC Jr, Lofton, S. Gliomas of the optic nerve or chiasm. Outcome by patients' age, tumor site, and treatment. J Neurosurg 1988; 68:85.
Benes, V, Julisova, I, Julis, I. Our treatment philosophy of gliomas of the anterior visual pathways. Childs Nerv Syst 1990; 6:75. Habiby, R, Silverman, B, Listernick, R, Charrow, J. Precocious puberty in children with neurofibromatosis type 1. J Pediatr 1995; 126:364. Imes, RK, Hoyt, WF. Magnetic resonance imaging signs of optic nerve gliomas in neurofibromatosis 1. Am J Ophthalmol 1991; 111:729. |
| Contributor | Philip A Gaudreau (Uniformed Services University) |
| Peer Reviewer | Alice Boyd Smith (Uniformed Services University) |
| Record Number | : 8508 |
| Created | 2007-11-19 21:12:46-05 |
| Modified | 2007-12-02 17:47:26.413862-05 |
| Category: | Neoplasm, glial |
| Location: | Nerve, central |
| Sublocation: | None Selected |
| MedPix® Medical Image Database Content Text and Images may be Copyright © 1999 - 2006 by the Original Contributors | |