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Gastric inflammatory fibroid polyp, MedPix™ : 5737 - Medical Image Database and Atlas
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More Like This ? Gastrointestinal
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More Like This ? Stomach
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More Like This ? Neoplasm, benign
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More Like This ? Gastric inflammatory fibroid polyp
Topic 5737 - Created: 2004-06-05 22:45:57-04 - Modified: 2004-06-08 01:37:50-04
ACR Index: 7.2

Inflammatory fibroid polyp (IFP) was initially reported by Vanek in 1949 (1) as a gastric submucosal lesion characterized histologically by whorls of fibrous tissue and blood vessels associated with an inflammatory infiltrate containing a high percentage of eosinophils (2). It is a rare benign lesion that may occur throughout the digestive tract, but is most often seen in the stomach (approximately 80%) (3).
Only scattered case reports have appeared in the radiology literature.

IFP is a solitary pedunculated or sessile lesion with an inflammatory basis. It is a rare benign lesion that may occur throughout the digestive tract, but is most often seen in the stomach (approximately 80%) (4). IFP in the stomach is usually located in the antrum or prepyloric region (5,6) . In large retrospective studies of gastric polyps, 3.1-4.5% were found to be IFP[6,7]. It is slightly more common in women (female:male ratio 1.6:1) (6).It is found in all age groups, although not often in children, and its maximal incidence is in the sixth decade (7). Most such polyps are small (<3.0 cm), but some as large as 19 cm in size have been reported . ileal lesions tend to be larger than those in the stomach (4).

Clinical manifestations of IFP are variable, depending on the location and size of the lesion. Most are small and asymptomatic. Nevertheless, it is able to cause anemia due to gastrointestinal bleeding, abdominal pain, vomiting, weight loss, intestinal obstruction or intussusception. In the stomach, it causes pyloric obstruction particularly with big size where the mass may occasionally prolapse through the pylorus, causing gastric outlet obstruction as seen in our case .
Physical examination is usually not conclusive.

Imagings such as upper GI series, ultrasonography or computed tomography can help diagnose the mass. The lesion may appear on barium studies as sessile or less frequently , pedonculated polyps with smooth or slightly lobulated contours . As a result they may be indistinguishable from adenomatous polyps in the stomach. Other inflammatory fibroid polyps that have a submucosal appearance can be mistaken for leiomyomas. Rarely , inflammatory fibroid polyps are larger or more lobulated , mimicking the appearance of polypoid gastric carcinomas. Unfortunately barium study was not performed in our patient , only abdominal ultrasound and CT scan were done.

Ultrasound can help in the determination of the location and the cystic or solid nature of the lesion particularly when the mass has a big size , as demonstrated with our patient. But when the tumor size is small , ultrasound can not be able to detect it , in contrast with barium series particularly double contrast studies which can depict smaller lesions.

CT scan is more helpful by demonstrating the location in the stomach , the size , and the solid nature of the mass. Contrast medium injection can demonstrate an increased uptake in the periphery of the lesion and in scattered areas of the mass but the final diagnosis is generally based on endoscopy and histological examination. There were no distinctive radiological features to differentiate IFPs from other mural or intraluminal lesions of the gastrointestinal tract.

Contributor Credits

Topic Author(s): dr jamal hedi saad
Submitted by: jamal saad - Author Info
Affiliation: Civilian Medical Center
Approved By: Angela Levy, M.D. - Editor Info
Affiliation: Georgetown University Hospital


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