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testicular feminization syndrome, MedPix™ : 289 - Medical Image Database and Atlas
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More Like This ? Endocrine (clinical)
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More Like This ? Congenital, genetic
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More Like This ? testicular feminization syndrome
Topic 289 - Created: 1997-11-07 00:00:00-05 - Modified: 2003-05-13 02:31:37-04

A genetic male (XY) inherits a genetic end-organ unresponsiveness to testosterone. This leads to a phenotypic female habitus. There are undescended testes, infertility (azoospermia) and increased incidence of of testicular neoplasms.

Presenting symptoms include primary amenorrhea, infertility, and puberty. Typically normal breast development occurs but without pubic or axillary hair.

Several popular actresses have been mentioned as examples of testicular feminization (androgen insensitivity) syndromes. Perhaps these are "Urban Myths" - but web searches routinely mention Jamie Lee Curtis and Kim Novak with this syndrome. If true, we should note that both were not only accepted as women, but more importantly as attractive and desireable women.

NOTE: We are unable to confirm their alleged medical histories.

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Contributor Credits

Topic Submitted by: James George Smirniotopoulos, M.D. - Author Info
Affiliation: Uniformed Services University
Topic approved by: James G. Smirniotopoulos, M.D. - Editor Info
Affiliation: Uniformed Services University

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