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MedPix® Medical Image DatabaseDisease Topic 289
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Contributor: James George Smirniotopoulos, M.D. - Uniformed Services University
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More Like This ? testicular feminization syndrome
Factoid 289 - Created: 1997-11-07 00:00:00-05 - Modified: 2003-05-13 02:31:37-04
A genetic male (XY) inherits a genetic end-organ unresponsiveness to testosterone. This leads to a phenotypic female habitus. There are undescended testes, infertility (azoospermia) and increased incidence of of testicular neoplasms.

Presenting symptoms include primary amenorrhea, infertility, and puberty. Typically normal breast development occurs but without pubic or axillary hair.

Several popular actresses have been mentioned as examples of testicular feminization (androgen insensitivity) syndromes. Perhaps these are "Urban Myths" - but web searches routinely mention Jamie Lee Curtis and Kim Novak with this syndrome. If true, we should note that both were not only accepted as women, but more importantly as attractive and desireable women.

NOTE: We are unable to confirm their alleged medical histories.

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http://www.nlm.nih.gov/medlineplus/ency/article/001180.htm

http://health.discovery.com/diseasesandcond/encyclopedia/2483.html

Location:
Endocrine (clinical) 		Sublocation:
none selected 		Category:
Congenital, genetic
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Prepared by: James George Smirniotopoulos, M.D.
Affiliation: Uniformed Services University - || - Author Profile
Approved by: James G. Smirniotopoulos, M.D.
Affiliation: Uniformed Services University - || - Editor Profile
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