chondrocalcinosis - MedPix® Medical Image Database and Teaching Files

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Disease Topic 4899
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Contributor: Pil Kang - Uniformed Services University

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chondrocalcinosis
Factoid 4899 - Created: 2003-06-25 14:38:01-04 - Modified: 2004-08-26 00:04:54-04

ACR Codes: 4.5
Definition of chondrocalcinosis is "pathologically or radiologically evident cartilage calcification." In various studies involving both autopsy and radiological surveys, the frequency of chondrocalcinosis ranges from as low as 0.42% (retrospective study of conventional x-rays in a wide age range of patients) to as high as 30% (autopsy and surgical specimens of elderly patients).

There are many conditions associated with chondrocalcinosis. Other than the idiopathic calcium pyrophosphate dihydrate deposition disease, those that have a high probability of association are:
   1) primary hyperparathyroidism
   2) hemosiderosis/hemochromatosis
   3) gout
   4) familial hypocalciuric hypercalcemia
   5) hypophosphatemia
   6) hypomagnesemia
   7) Bartter's syndrome
   8) hypothyroidism
   9) neuropathic osteoarthropathy
   10) amyloidosis
   11) trauma
   12) corticosteroid therapy (long-term)
   13) aging
of these, the top three diagnoses that should be mentioned along with the idiopathic variety should be: primary hyperparathyroidism, hemosiderosis/hemochromatosis, and gout. Frequency of hyperparathyroidism in patients with chondrocalcinosis has been reported from 0-15%, and frequency of chondrocalcinosis in patients with hyperparathyroidism has been reported to be 18-40%. Frequency of chondrocalcinosis in patients with hemochromatosis has been reported to be 41%.

Reference(s):
Resnick D. Bone and Joint Imaging, 2/e. W.B. Saunders Co.:1996.

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Location: MSK - Musculoskeletal	Sublocation: Soft-tissues	Category: Differential Diagnosis
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Prepared by: Pil Kang
Affiliation: Uniformed Services University - || -
Approved by: Philip A Dinauer
Affiliation: Civilian Medical Center - || -

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