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Cell Age and Body Age, Cell Turnover, Cell Lifespan, MedPix™ : 9278 - Medical Image Database and Atlas
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More Like This ? Cell Age and Body Age, Cell Turnover, Cell Lifespan
Topic 9278 - Created: 2009-08-08 09:49:36-04 - Modified: 2012-12-28 15:46:56.358804-05

Most of the cells in the human body "turnover" - that is cells die, but are usually replaced. This programmed cell death is called "apoptosis".

Each tissue and cell type has it's own lifespan:

• Intestinal Lining: ~ 5 days

• Skin surface: ~ 14 days

• Red Blood Cells (RBCs): ~ 120 days

• Liver Cells: 300 - 500 days

• Bone cells: ~ 7-10 yrs

• Muscle cells: 15 yrs

• Intestine muscle and wall: ~ 16 yrs

In addition to the "cellular turnover" - atoms in our molecules are constantly exchanging with similar atoms from our environment. About 98% of the atoms are changed every year ... and ALL of the atoms are exchanged every five to seven years.
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Neurons in the brain cortex may not "turnover" at all. However, the smell sensing ("olfactory" cells of the nasal vault are replaced by Neural progenitor cells (NPCs) that are made in the subventricular zone and then migrate to the nose. The subgranular zone of the dentate gyrus (hippocampus) produces new granular cells that migrate, mature, and become integrated into the brain.

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Contributor Credits

Topic Submitted by: James G. Smirniotopoulos, M.D. - Author Info
Affiliation: Uniformed Services University
Topic approved by: James G. Smirniotopoulos, M.D. - Editor Info
Affiliation: Uniformed Services University

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