Discussion Author: Eva M. Smietana
Neuronal migration occurs beginning the seventh week of gestation with the migration of neurons from the germinal matrix, which lines the lateral and third ventricles, to the surface of the brain. If there is disruption of the normal process of neuronal generation and cellular migration, a spectrum of developmental anomalies can occur. Schizencephaly is one such abnormality. Schizencephaly, meaning â€śsplit brainâ€ť, is seen as a grey-matter lined cleft, which extends from the ependymal surface of the brain through the white matter to the pia.
Two types of Schizencephaly are recognized: closed-lip and open-lip. With closed-lip schizencephaly, the cleft walls are apposed. In the open-lip variety, the walls of the cleft are separated and filled with CSF. The closed-lip variety may be difficult to detect, and imaging may only show a slight out-pouching of CSF at the ependymal surface of the cleft. The clefts can occasionally be very large.
Schizencephalies are most commonly located in the supratentorial space and are seen most frequently in the frontal (44%), frontoparietal (30%), and occipital (19%) lobes. The clefts can be bilateral and have a symmetric or asymmetric appearance.
Topic Details: Schizencephaly :: :: Search for other Topics with Schizencephaly
Highlight this =>[ Schizencephaly ]<= for a Popup Search Tool