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Sister Mary Joseph Nodule, MedPix™ : 8777 - Medical Image Database and Atlas
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More Like This ? Sister Mary Joseph Nodule
Topic ID: 8777 - Modified: 2008-07-11 21:06:26.896671-04 - Created: 2008-07-11 20:34:10-04
ACR Index: 7.3

The finding of a hard subcutaneous nodule at the umbilicus secondary to metastatic carcinoma is referred to as a Sister Mary Joseph Nodule. The sign was noticed by a Franciscan nun, after whom it is named. Sister Mary Joseph worked as a surgical assistant to William J Mayo. However it was not until 1949, 10 years after her death that Sir Hamilton Bailey used the term in his textbook Physical Signs in Clinical Surgery

This sign often due to metastatic intra-abdominal malignancy signals advanced disease with a poor prognosis. Average survival after discovery is about 10 to 11 months.

The most common malignancies associated with a Sister Mary Joseph Nodule are adenocarcinomas of the stomach, colon, pancreas and ovary.

Spread to the umbilicus is thought to occur via lymphatic, vascular and defunct embryological connections. This case highlights the continued importance of physical examination findings in determining patient diagnosis and prognosis.

This is also known as a Sister Mary Joseph Node

Topic Contributor Credits

Topic Submitted by: Amit Kumar Sanghi - Author Info
Affiliation: National Capital Consortium
Topic approved by: Albert V Porambo - Editor Info
Affiliation: Civilian Medical Center

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