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Brain Lesion Locator™:
Differential Diagnosis by Location

Developed by: James G. Smirniotopoulos, M.D.

Uniformed Services University of the Health Sciences
Bethesda,MD USUHS Radiology Homepage

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Portions Copyright © 1987-2007 by James G. Smirniotopoulos, M.D.




























Search MedPix™ - Cerebello-Pontine Angle (CPA) Cistern (extra-axial) 

  • Vestibular Schwannoma (what this is) -
  • Meningioma
  • Epidermoid (doesn't enhance, undulating margin)
  • Glomus Tumor, Mets, Endolymphatic Sac Tumor
  • Extension from 4th or Primary CPP and Ependymoma

 









Search MedPix™ - Cerebello-Pontine Angle (CPA) Cistern (extra-axial)

  • Vestibular Schwannoma
  • Meningioma (what this is) -
  • Epidermoid (doesn't enhance, undulating margin) -
  • Glomus Tumor, Mets, Endolymphatic Sac Tumor
  • CPP and Ependymoma Extenting from 4th and/or Primary in CPA

 









Search MedPix™ - 4th Ventricular / Vermian Mass

  • PNET (medulloblastoma) -
    • usually HYPERDENSE on NCT
  • Ependymoma -
    • usually HETEROGENEOUS w/Ca++ and small "cysts"
  • Choroid Plexus Papilloma (adults)

 









Search MedPix™ - Hemispheric Cerebellar Mass / Cyst with Nodule

  • Pilocytic Astrocytoma (5- 15 yrs) -
  • Hemangioblastoma (35-45 yrs) -
  • Other Hemispheric Masses:
    • Mets, Infarction, Abscess

 









Search MedPix™ - Sella and Parasellar / Suprasellar

  • Pituitary Adenoma (adults) -
  • Craniopharyngioma
  • Hypothalamic Glioma (children)
  • Chordoma, Meningioma, Mets
  • Langerhans Histiocytosis, Germinioma, Lymphoma, Sarcoid
  • Aneurysms!  -

 









Search MedPix™ - 3rd Ventricle


 
 
 
 
 
 









Search MedPix™ - Thalamus & Basal Ganglia

  • Bilateral Symmetric (toxic/metabolic): -
    • Putamen - Methanol
    • Globus Pallidus - CO Poisoning
    • Genetic Disorders
  • Bilateral Asymmetric (hematogenous):
    • Infection (Toxoplasmosis, etc.)
    • Metastasis
  • Unilateral (acquired/neoplastic):
    • Thalamus Glioma (astrocytoma)
    • Hypertensive Hematoma (Dx by exclusion)  -

 
 
 









Search MedPix™ - Lateral Ventricle

  • F. Monro
    • Subependymal Giant Cell Astro -
    • Subependymoma
  • Body
    • Subependymoma, etc.
  • Trigone
    • Child - CPP (Choroid Plexus Papilloma)  -
    • Adult - Meningioma


Search MedPix™ - Intraventricular Neoplasms

  • Ependymoma (and subependymoma) -
  • Choroid plexus papilloma -
  • Subependymal giant cell astro. -
  • Meningioma
  • Colloid cyst (3rd) -
  • Dermoid or Epidermoid Inclusion Cyst
  • Central neurocytoma
  • Medulloblastoma (4th) -
  • Mets, lymphoma, Germ Cell

 









Search MedPix™ - Pineal Region (Quadrigeminal Cistern)

  • Germ Cell Tumor -
    • ("Pinealoma" is really a seminoma = germinoma = dysgerminoma = "atypical teratoma")
  • Pineal Parenchyma
    • (mature Pineocytoma, immature Pineoblastoma)
  • Pineal Cyst  -
  • Extension of Glioma (Astrocytoma)
    • from corpus callosum, tectum, or thalamus
  • Meningioma
  • Lipoma  -
  • Vein of Galen Malformation  -
  • Epidermoid Inclusion Cyst  -

 










 
 










 
 










 
 









Search MedPix™ - Corpus Callosum 

  • Enlarged, Expanded, or Enhancing -
    • (Astrocytoma, Lymphoma)
  • Destructive, Geographic
    • (White Matter Disease - Leukoencephalopathy)
  • Patchy Periventricular
    • Vascular (HT change, "Leukoariosis")
    • Multifocal Rings - Toxo Abscess in AIDS
  • Uniformly Periventricular
    • Hydrocephalic (hydrostatic) edema


Corpus Callosum-Splenium

  • Marchiafava-Bignami Disease
  • High Altitude Cerebral Edema (HACE)
  • ADL (Adrenoleukodystrophy)

 
 

Occipital White Matter

  • ADL (Adrenoleukodystrophy)
  • PRES (Posterior Reversible Encephalopathy Syndrome) -
    • Hypertensive Encephalopathy
    • Ecclampsia/Preeclampsia
    • Cyclosporin Tx


Search MedPix™ - Generalized White Matter

  • Periventricular
    • Multiple Sclerosis -
    • Hypertensive / Ishemic Changes
    • "Normal Changes" of Ageing
    • Hydrostatic/Hydrocephalic Edema
  • Subcortical
    • PML (Progressive Multifocal Leukoencephalopathy) -

 









Search MedPix™ - Cortex (Gray Matter)

  • Gray Matter Ribbon
    • Ischemia (w/ or w/o Infarction)
    • Hyperemia with Migraine
    • Hyperemia after Seizure
    • Hypertensive Encephalopathy
    • Ecclampsia, Cyclosporin
    • Encephalitis (usually HSV) -
    • Meningitis, Meningoencephalitis
    • Sturge-Weber Disease (Ca++)
    • Meningioangiomatosis (Ca++)

  • Gray & White Wedge
    • Cerebral Infarction -
    • Cortical Dysplasia
    • Cortical Tuber (Tuberous Sclerosis) -
    • DNET -

 
 









Search MedPix™ - Epidural Space 

  • Epidural Hematoma -
  • Epidural Empyema
  • Dura / Epidural Mets
    • Prostate, Breast, Lymphoma
  • Granulomatous Disease (e.g. Sarcoid, Tuberculosis, Fungal)

 









Search MedPix™ - Subdural Space 

  • Subdural Hematoma -
  • Subdural Empyema
  • Dural/Subdural Mets
    • Prostate, Breast, Lymphoma
  • Granulomatous Disease (e.g. Sarcoid, TB, Fungal)

 










 
 










 
 










 
 









This page created and maintained by:

James G. Smirniotopoulos, M.D.
Professor of Radiology, Neurology, and Biomedical Informatics
Chairman, Department of Radiology and Radiological Sciences
Uniformed Services University of the Health Sciences
4301 Jones Bridge Road
Bethesda, MD 20814
Voice: 301-295-3145
FAX: 301-295-3893

Comments or Questions - Send EMail about this site.



Portions Copyright © 1987-2004 by James G. Smirniotopoulos, M.D.
Last Revision: 8:29 AM 1/6/2007

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