58 year old man with 2 month history of personality changes and headache.
Expansile mass lesion involving the splenium of the corpus callosum. The mass enhances homogeneously and produces a moderate amount of surrounding vasogenic edema. The mass is not particularly bright on FLAIR and T2.
â€¢ Glioma (astrocytoma, oligodendroglioma, oligoastrocytoma
â€¢ Primary CNS Lymphoma
â€¢ Tumefactive Demyelination
Â» MS, ADEM, Marchiafava-Bignami Disease, etc.
â€¢ Infection (Abscess, encephalitis, ventriculitis)
â€¢ Metastatic disease
Dx: Diffuse Large B-Cell Lymphoma
Dx Confirmed by: Biopsy and pathologic examination
Radiation and chemotherapy
The increased cellularity of "small round blue cell tumors" - like lymphoma - often has a characteristic imaging appearance of high attenuation on pre-contrast CT, low signal on T1 and T2 MR, and low ADC/high signal on DWI.
Diffuse Large Cell Lymphoma
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